Dichotomous Indium-111 labeled leukocyte scan findings while evaluating osteomyelitis in a failed mandibular graft

نویسندگان

  • Jack McEwan Division of Nuclear Medicine, Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA, USA
  • Simin Dadparvar Division of Nuclear Medicine, Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA, USA
  • Walter Slizofski Division of Nuclear Medicine, Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA, USA
چکیده مقاله:

Markedly elevated111 In labeled leukocyte activity suggestive of acute osteomyelitis was observed in a region of a composite mandibular allograft that was photon deficient on 99mTc MDP bone scintigraphy. This finding was later confirmed by surgical pathology. The patient was treated with intravenous antibiotics and returned two months later with persistent bone infection. The foHow-up three phase bone and 111In labeled leukocyte scans were performed. The photopenic region noted in the previous bone scan demonstrated a mild interval increase in activity, while the 111In labeled leukocyte activity was essentially normal. Additional imaging of the composite allograft was then performed using 67Ga-citrate at 24 and 48 hours post injection. These images revealed focal areas of increased Gallium activity in the photopenic region of the graft exhibiting normal mIn leukocyte activity. The tissue culture comfirmed underlying chronic osteomyelitis. We conclude that normal uptake on niIn labeled leukocyte and photon deficient regions on 99mTc bone scintigraphy do not necessarily exclude the presence of chronic osteomyelitis. In the management of patients who have been on prolonged antibiotic therapy with persistent infection, 67Ga scintigraphy is warranted.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

dichotomous indium-111 labeled leukocyte scan findings while evaluating osteomyelitis in a failed mandibular graft

markedly elevated111 in labeled leukocyte activity suggestive of acute osteomyelitis was observed in a region of a composite mandibular allograft that was photon deficient on 99mtc mdp bone scintigraphy. this finding was later confirmed by surgical pathology. the patient was treated with intravenous antibiotics and returned two months later with persistent bone infection. the fohow-up three pha...

متن کامل

Indium-111 labeled leukocyte accumulation in extremity soft tissue sarcoma

Nuclear medicine labeled leukocyte whole-body scintigraphy is commonly used to identify a source of infection in a patient with fever of unknown origin. White blood cells can also localize to other sites of inflammation, including sometimes tumors. A patient with a large myxofibrosarcoma in his left forearm was scanned due to chronic low-grade fever and persistent leukocytosis. This case demons...

متن کامل

Peripheral graft infection due to Staphylococcus aureus without abnormal findings by 99mTc-HMPAO-labeled-leukocyte scan.

Here, we present the case of an extremely subtle peripheral graft infection caused by Staphylococcus aureus. The lack of local signs and the negativity of all imaging studies, including (99m)Tc-HMPAO-Labelled-Leukocyte Scan which is reported to have 100% sensitivity, delayed the diagnosis and therapy, which were both provided by surgery.

متن کامل

Indium-111-labeled Platelets: Effect of Heparin

The goal of heparin therapy in deep vein thrombosis is to prevent thrombus extension. The relationship between thrombus extension and the results of coagulation tests used to monitor heparin therapy is unclear. To explore this relationship, we studied the effect of several heparin regimens on the accretion of indium-111-labeled platelets on fresh venous thrombi, as detected by gamma imaging, an...

متن کامل

Using Indium-111-labeled Autologous Platelets

The feasibility of imaging the inflammatory response to acute transmural myocardial infarction in man using biologically active indium-111 ("'ln)-labeled autologous leukocytes was assessed in 36 patients. Indium-111 leukocytes (approximately 500 ,tCi) were injected i.v. 18-112 hours after the onset of chest pain. Cardiac imaging was performed 24 hours later with a mobile gamma camera. Twenty-on...

متن کامل

Effect of leukocyte antibodies on the fate in vivo of indium-111-labeled granulocytes.

The effect of different leukocyte antibodies on the fate in vivo of granulocytes is not known. Thus, the optimum in vitro serologic tests to determine a safe and effective granulocyte transfusion or to diagnose immune destruction of granulocytes in other clinical situations have not been identified. We have studied the effect of granulocyte agglutinating (GA), granulocytotoxic (GC), and lymphoc...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 5  شماره 1

صفحات  13- 18

تاریخ انتشار 1997-12-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023